A Comparison of Targeted Layered Containment Strategies for a Flu Pandemic in Three US Cities

We study strategies for targeted layered containment of an influenza pandemic in three US cities: Miami, Seattle, and Chicago. Differences in demographic, geographic, and other structures lead to differences in the social interaction networks in the three cities. This has consequences for how the containment strategies should be applied to mitigate the spread. We use large-scale simulations to study these containment strategies and show differences in outcomes across the three cities.